Serum Level of Interleukin-6 in Patients with Oral Tongue Squamous cell Carcinoma

Authors

  • Ali Esfahani Hematology and Oncology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
  • Alireza Lotfi Hematology and Oncology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
  • Gholamreza Bayazian Department of Otorhinolaryngology, Hazrat Rasool hospital, Faculty of Medicine, Iran University of Medical Sciences, Tehran, Iran.
  • Nikzad Shahidi Department of Otorhinolaryngology, Imam Reza Hospital, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran.
  • Rasoul Estakhri Department of Pathology, Imam Reza hospital, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran.
  • Rezvan Notash Department of Otorhinolaryngology, Imam Reza Hospital, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran.
  • Shahin AbdollahiFakhim Department of Otorhinolaryngology, Imam Reza Hospital, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran.
Abstract:

Introduction: The clinical outcome of patients with squamous cell carcinoma (SCC) located in the head and neck has remained poor despite ongoing advances in diagnosis and management. Interleukin-6(IL-6) is a multi-functional cytokine that plays an important role in the process of cell differentiation and is increased in several malignancies. The aim of this study was to investigate the serum levels of interleukin-6 in patients with oral tongue SCC.   Materials and Methods: In a cross-sectional study, 17 patients with oral tongue SCC were compared with the same number of age- and gender-matched healthy subjects. Serum IL-6 level fluctuation was determined using an immunological technique, before detecting its possible association with the subjects’ age, gender, drinking and smoking history, cancer site, and disease severity.   Results: The intensity of serum IL-6 in patients with oral tongue SCC was statistically significantly higher than that in healthy subjects (P

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Journal title

volume 27  issue 3

pages  207- 211

publication date 2015-05-01

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